Recent discoveries characterizing the molecular basis of lung cancer brought fundamental changes in lung cancer treatment. The authors review the molecular pathogenesis of lung cancer, including genomic abnormalities, targeted therapies, and resistance mechanisms, and discuss lung cancer imaging with novel techniques. Knowledge of the molecular basis of lung cancer is essential for radiologists to properly interpret imaging and assess response to therapy.

Quantitative and functional imaging helps assessing the biologic behavior of lung cancer.

Acad Radiol. 2011 Jan 27;
Authors: Nishino M, Jackman DM, Hatabu H, Jänne PA, Johnson BE, Van den Abbeele AD
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