Despite the well-known benefits of subcutaneous immunotherapy (SCIT), adverse reactions include both local reactions (LRs) and systemic reactions.

An LR is a well-known adverse event associated with SCIT injections and is defined as any swelling located at or near the injection site following allergen injection. Concerns that LRs might predict systemic reactions have historically motivated allergists to dose adjust for LRs.

More recent data have dispelled this notion, although many allergists continue to dose adjust for other reasons. This article discusses the historical response to LRs and dose adjustments and reviews the most recent literature addressing LRs to SCIT.

Treatment options, although they are either unproven or not studied, are offered as an alternative to routine dose adjustments for LRs. Education remains the foundation of physician–patient communication concerning LRs.