Conflict of interest: V. Cottin reports personal fees for lecturing and consultancy, and non-financial support for travel from Actelion, grants, personal fees for development of educational material, lecturing and consultancy, and non-financial

support for travel from Boehringer Ingelheim, personal fees for consultancy from Bayer/MSD, GSK and Galapagos, personal fees for adjudication board work from Gilead, personal fees for lecturing and consultancy from Novartis, grants, personal fees for lecturing and consultancy, and non-financial support for travel from Roche, grants from Sanofi, personal fees for data monitoring committee work from Promedior and Celgene, outside the submitted work.