Atopic dermatitis (AD) is a chronic, relapsing form of inflammatory skin disease, affecting approximately 10% of children in the United States.1 AD has been associated with sleep disturbances, along with various comorbid allergic conditions, resulting in poor quality of life. In the last decade, studies have demonstrated an epidermal skin barrier defect, caused by various genetic mutations, to be an additional predisposing factor.2 Early childhood caries (ECC), a chronic diet-mediated infectious oral disease, has been reported to be the most common chronic childhood disease in the United States.