Tryptase is mainly implicated in events downstream of mast cell degranulation. Here we show that tryptase additionally has a role in intranuclear core histone processing, thereby affecting epigenetic regulation and cellular differentiation in mast cells.
Author:Fabio R. Melo, Ola Wallerman, Aida Paivandy, Gabriela Calounova, Ann-Marie Gustafson, Benjamin R. Sabari, Giuliano Zabucchi, C David Allis, Gunnar Pejler
