HEATED HUMIDIFIED HIGH-FLOW NASAL OXYGEN IN ADULTS: MECHANISMS OF ACTION AND CLINICAL IMPLICATIONS. Chest. 2015 Mar 5; Authors: Spoletini G, Alotaibi M, Blasi F, Hill NS Abstract Abstract: Traditionally, nasal oxygen therapy has been delivered at low flows via nasal cannulae. In recent years, nasal cannulae designed to administer heated and humidified air/oxygen mixtures at high flows (up to 60 L/min) have been gaining popularity. These high-flow nasal cannula (HFNC) systems enhance patients' comfort and tolerance compared to traditional high flow oxygenation systems, such as nasal masks and nonrebreathing systems. By delivering higher flow rates, HFNC is less apt than traditional oxygenation systems to permit entrainment of room air during patient inspiration. Combine...