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Airborne dissemination of transmissible bacterial species in cystic fibrosis

bacteriaDelivery of multidisciplinary care by experienced teams in specialist units has conferred considerable benefits in care for individuals with cystic fibrosis (CF), with significant improvements in clinical outcome and survival figures. However, one particular concern of congregating patients at specialist CF centres is the potential for cross-infection.

Over the past decade, the emergence and spread of clonal (transmissible) Pseudomonas aeruginosa strains among patients with CF has become an international problem.

Case series suggest that initial infection with clonal P. aeruginosa strains may be more difficult to eradicate,4 and in cohort studies chronic infection is associated with worse clinical outcomes.

The mechanism of spread of P. aeruginosa between patients with CF is unresolved. Potential routes include direct or indirect contact, droplet spread of relatively large infectious particles that travel short distances or airborne spread of...

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